Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ(1–40) peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furth...

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Detalles Bibliográficos
Autores principales: Lu, Lihua, Zhong, Hai-Jing, Wang, Modi, Ho, See-Lok, Li, Hung-Wing, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588514/
https://www.ncbi.nlm.nih.gov/pubmed/26419607
http://dx.doi.org/10.1038/srep14619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588514/
https://www.ncbi.nlm.nih.gov/pubmed/26419607
http://dx.doi.org/10.1038/srep14619

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