Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ(1–40) peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furth...

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Autores principales: Lu, Lihua, Zhong, Hai-Jing, Wang, Modi, Ho, See-Lok, Li, Hung-Wing, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588514/
https://www.ncbi.nlm.nih.gov/pubmed/26419607
http://dx.doi.org/10.1038/srep14619
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author Lu, Lihua
Zhong, Hai-Jing
Wang, Modi
Ho, See-Lok
Li, Hung-Wing
Leung, Chung-Hang
Ma, Dik-Lung
author_facet Lu, Lihua
Zhong, Hai-Jing
Wang, Modi
Ho, See-Lok
Li, Hung-Wing
Leung, Chung-Hang
Ma, Dik-Lung
author_sort Lu, Lihua
collection PubMed
description We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ(1–40) peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ(1–40) peptide on the basis of their emission response.
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spelling pubmed-45885142015-10-13 Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes Lu, Lihua Zhong, Hai-Jing Wang, Modi Ho, See-Lok Li, Hung-Wing Leung, Chung-Hang Ma, Dik-Lung Sci Rep Article We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ(1–40) peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ(1–40) peptide on the basis of their emission response. Nature Publishing Group 2015-09-30 /pmc/articles/PMC4588514/ /pubmed/26419607 http://dx.doi.org/10.1038/srep14619 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lu, Lihua
Zhong, Hai-Jing
Wang, Modi
Ho, See-Lok
Li, Hung-Wing
Leung, Chung-Hang
Ma, Dik-Lung
Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
title Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
title_full Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
title_fullStr Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
title_full_unstemmed Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
title_short Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
title_sort inhibition of beta-amyloid fibrillation by luminescent iridium(iii) complex probes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588514/
https://www.ncbi.nlm.nih.gov/pubmed/26419607
http://dx.doi.org/10.1038/srep14619
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