Cargando…

Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ(1–40) peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Lihua, Zhong, Hai-Jing, Wang, Modi, Ho, See-Lok, Li, Hung-Wing, Leung, Chung-Hang, Ma, Dik-Lung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588514/ https://www.ncbi.nlm.nih.gov/pubmed/26419607 http://dx.doi.org/10.1038/srep14619

Ejemplares similares

Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine
por: Lu, Lihua, et al.
Publicado: (2016)

Luminescent chemosensors by using cyclometalated iridium(iii) complexes and their applications
por: Ma, Dik-Lung, et al.
Publicado: (2017)

A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α
por: Lu, Lihua, et al.
Publicado: (2016)

Luminescent Iridium(III) Chemosensor for Tandem Detection of F(–) and Al(3+)
por: Liu, Jin-Biao, et al.
Publicado: (2017)

Iridium-based probe for luminescent nitric oxide monitoring in live cells
por: Wu, Chun, et al.
Publicado: (2018)

A Label-Free Luminescent Switch-On Assay for ATP Using a G-Quadruplex-Selective Iridium(III) Complex
por: Leung, Ka-Ho, et al.
Publicado: (2013)

A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2
por: Vellaisamy, Kasipandi, et al.
Publicado: (2018)

Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform
por: Liu, Jinshui, et al.
Publicado: (2017)

A Highly Selective and Non-Reaction Based Chemosensor for the Detection of Hg(2+) Ions Using a Luminescent Iridium(III) Complex
por: Chan, Daniel Shiu-Hin, et al.
Publicado: (2013)

Luminescent turn-on detection of Hg(II) via the quenching of an iridium(III) complex by Hg(II)-mediated silver nanoparticles
por: Liu, Jinshui, et al.
Publicado: (2017)

Luminescent Iridium(III) Complexes Supported by N-Heterocyclic Carbene-based C^C^C-Pincer Ligands and Aromatic Diimines
por: Chung, Lai-Hon, et al.
Publicado: (2015)

A Colorimetric and Luminescent Dual-Modal Assay for Cu(II) Ion Detection Using an Iridium(III) Complex
por: Ma, Dik-Lung, et al.
Publicado: (2014)

Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity
por: Lu, Lihua, et al.
Publicado: (2015)

A colorimetric chemosensor for Cu(2+) ion detection based on an iridium(III) complex
por: Wang, Modi, et al.
Publicado: (2014)

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
por: Ma, Dik-Lung, et al.
Publicado: (2019)

An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells
por: Liu, Jin-Biao, et al.
Publicado: (2016)

An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
por: Zhong, Hai-Jing, et al.
Publicado: (2015)

Iridium(III) Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
por: Davis, Keersten M., et al.
Publicado: (2015)

A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ
por: Miao, Xiangmin, et al.
Publicado: (2017)

Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex
por: Ma, Dik-Lung, et al.
Publicado: (2013)

Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform
por: Miao, Xiangmin, et al.
Publicado: (2016)

Cell imaging of dopamine receptor using agonist labeling iridium(iii) complex
por: Vellaisamy, Kasipandi, et al.
Publicado: (2017)

Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe
por: Lin, Sheng, et al.
Publicado: (2015)

Synthesis and Luminescence Properties of Iridium(III) Azide- and Triazole-Bisterpyridine Complexes
por: Goldstein, Daniel C., et al.
Publicado: (2013)

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior
por: Wang, Modi, et al.
Publicado: (2016)

Acid-base-induced fac → mer isomerization of luminescent iridium(iii) complexes
por: Yu. Gitlina, Anastasia, et al.
Publicado: (2022)

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe
por: Leung, Ka-Ho, et al.
Publicado: (2015)

Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds
por: Liu, Li-Juan, et al.
Publicado: (2016)

G-quadruplexes for luminescent sensing and logic gates
por: He, Hong-Zhang, et al.
Publicado: (2013)

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound
por: Liu, Li-Juan, et al.
Publicado: (2017)

Spectroscopic and Theoretical Investigation of Color Tuning in Deep-Red Luminescent Iridium(III) Complexes
por: Stonelake, Thomas M., et al.
Publicado: (2020)

A highly selective, label-free, homogenous luminescent switch-on probe for the detection of nanomolar transcription factor NF-kappaB
por: Ma, Dik-Lung, et al.
Publicado: (2011)

A Ruthenium(II) Complex Supported by Trithiacyclononane and Aromatic Diimine Ligand as Luminescent Switch-On Probe for Biomolecule Detection and Protein Staining
por: Wong, Chun-Yuen, et al.
Publicado: (2014)

Luminescent detection of DNA-binding proteins
por: Leung, Chung-Hang, et al.
Publicado: (2012)

Luminescent ruffled iridium(iii) porphyrin complexes containing N-heterocyclic carbene ligands: structures, spectroscopies and potent antitumor activities under dark and light irradiation conditions
por: Lam, Tsz-Lung, et al.
Publicado: (2018)

Polyphenolic Biflavonoids Inhibit Amyloid-Beta Fibrillation and Disaggregate Preformed Amyloid-Beta Fibrils
por: Choi, Erika Y., et al.
Publicado: (2020)

Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection
por: Nao, Sang-Cuo, et al.
Publicado: (2020)

A Phosphorescent Iridium(III) Complex‐Modified Nanoprobe for Hypoxia Bioimaging Via Time‐Resolved Luminescence Microscopy
por: Lv, Wen, et al.
Publicado: (2015)

Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes
por: Venkatesh, V., et al.
Publicado: (2017)

Mixed-carbene cyclometalated iridium complexes with saturated blue luminescence
por: Na, Hanah, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_39mt9q5ba1fm8te83oebeeefru