Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance

Emergence of genetic resistance against kinase inhibitors poses a great challenge for durable therapeutic response. Here, we report a novel mechanism of JAK2 kinase inhibition by fedratinib (TG101348) that prevents emergence of genetic resistance. Using in vitro drug screening, we identified 211 ami...

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Detalles Bibliográficos
Autores principales: Kesarwani, Meenu, Huber, Erika, Kincaid, Zachary, Evelyn, Chris R., Biesiada, Jacek, Rance, Mark, Thapa, Mahendra B., Shah, Neil P., Meller, Jarek, Zheng, Yi, Azam, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588578/
https://www.ncbi.nlm.nih.gov/pubmed/26419724
http://dx.doi.org/10.1038/srep14538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588578/
https://www.ncbi.nlm.nih.gov/pubmed/26419724
http://dx.doi.org/10.1038/srep14538

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