Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or...

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Detalles Bibliográficos
Autores principales: Pulcini, Serena, Staines, Henry M., Lee, Andrew H., Shafik, Sarah H., Bouyer, Guillaume, Moore, Catherine M., Daley, Daniel A., Hoke, Matthew J., Altenhofen, Lindsey M., Painter, Heather J., Mu, Jianbing, Ferguson, David J. P., Llinás, Manuel, Martin, Rowena E., Fidock, David A., Cooper, Roland A., Krishna, Sanjeev
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588581/
https://www.ncbi.nlm.nih.gov/pubmed/26420308
http://dx.doi.org/10.1038/srep14552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588581/
https://www.ncbi.nlm.nih.gov/pubmed/26420308
http://dx.doi.org/10.1038/srep14552

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