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Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome
BACKGROUND: DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role in intestinal development is limited. RESULTS: We use whole genome bisulfite sequencing, and find that differentiation of mouse colonic intest...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589031/ https://www.ncbi.nlm.nih.gov/pubmed/26420038 http://dx.doi.org/10.1186/s13059-015-0763-5 |