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In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity
Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2(−/−)) mice is severely reduced, although the underlying mechanisms are largely unknow...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589058/ https://www.ncbi.nlm.nih.gov/pubmed/26451322 http://dx.doi.org/10.1080/2162402X.2015.1047579 |