Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response

DNA double-strand break repair involves phosphorylation of histone variant H2AX (‘γH2AX’), which accumulates in foci at sites of damage. In current models, the recruitment of multiple DNA repair proteins to γH2AX foci depends mainly on recognition of this ‘mark’ by a single protein, MDC1. However, D...

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Detalles Bibliográficos
Autores principales: Kleiner, Ralph E., Verma, Priyanka, Molloy, Kelly R., Chait, Brian T., Kapoor, Tarun M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589150/
https://www.ncbi.nlm.nih.gov/pubmed/26344695
http://dx.doi.org/10.1038/nchembio.1908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589150/
https://www.ncbi.nlm.nih.gov/pubmed/26344695
http://dx.doi.org/10.1038/nchembio.1908

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