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Molecular Binding Mechanism of TtgR Repressor to Antibiotics and Antimicrobials

A disturbing phenomenon in contemporary medicine is the prevalence of multidrug-resistant pathogenic bacteria. Efflux pumps contribute strongly to this antimicrobial drug resistance, which leads to the subsequent failure of clinical treatments. The TtgR protein of Pseudomonas putida is a HTH-type tr...

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Detalles Bibliográficos
Autores principales: Fernandez-Escamilla, Ana Maria, Fernandez-Ballester, Gregorio, Morel, Bertrand, Casares-Atienza, Salvador, Ramos, Juan Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589371/
https://www.ncbi.nlm.nih.gov/pubmed/26422008
http://dx.doi.org/10.1371/journal.pone.0138469