Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses

DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs) that recognize both viruses and demonstrate robust neutralizing activity. Eac...

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Detalles Bibliográficos
Autores principales: Bounds, Callie E., Kwilas, Steven A., Kuehne, Ana I., Brannan, Jennifer M., Bakken, Russell R., Dye, John M., Hooper, Jay W., Dupuy, Lesley C., Ellefsen, Barry, Hannaman, Drew, Wu, Hua, Jiao, Jin-an, Sullivan, Eddie J., Schmaljohn, Connie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589376/
https://www.ncbi.nlm.nih.gov/pubmed/26422247
http://dx.doi.org/10.1371/journal.pone.0137786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589376/
https://www.ncbi.nlm.nih.gov/pubmed/26422247
http://dx.doi.org/10.1371/journal.pone.0137786

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