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Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs) that recognize both viruses and demonstrate robust neutralizing activity. Eac...
Autores principales: | Bounds, Callie E., Kwilas, Steven A., Kuehne, Ana I., Brannan, Jennifer M., Bakken, Russell R., Dye, John M., Hooper, Jay W., Dupuy, Lesley C., Ellefsen, Barry, Hannaman, Drew, Wu, Hua, Jiao, Jin-an, Sullivan, Eddie J., Schmaljohn, Connie S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589376/ https://www.ncbi.nlm.nih.gov/pubmed/26422247 http://dx.doi.org/10.1371/journal.pone.0137786 |
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