Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets

AIMS/HYPOTHESIS: Patients diagnosed with type 1 or type 2 diabetes have elevated levels of coagulation factor VIIa (FVIIa) and its receptor tissue factor (TF) in their bloodstream. This may affect the fate of the beta cells. We aimed to study the effects of TF/FVIIa signalling on cytokine-induced be...

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Detalles Bibliográficos
Autores principales: Edén, Desirée, Siegbahn, Agneta, Mokhtari, Dariush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589554/
https://www.ncbi.nlm.nih.gov/pubmed/26271343
http://dx.doi.org/10.1007/s00125-015-3729-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589554/
https://www.ncbi.nlm.nih.gov/pubmed/26271343
http://dx.doi.org/10.1007/s00125-015-3729-y

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