miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker development

ABSTRACT: MicroRNAs play a crucial role in the regulation of cell growth and differentiation. Mice with genetic deletion of miR-375 exhibit impaired glycemic control due to decreased β-cell and increased α-cell mass and function. The relative importance of these processes for the overall phenotype o...

Descripción completa

Detalles Bibliográficos
Autores principales: Latreille, Mathieu, Herrmanns, Karolin, Renwick, Neil, Tuschl, Thomas, Malecki, Maciej T., McCarthy, Mark I., Owen, Katharine R., Rülicke, Thomas, Stoffel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589563/
https://www.ncbi.nlm.nih.gov/pubmed/26013143
http://dx.doi.org/10.1007/s00109-015-1296-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589563/
https://www.ncbi.nlm.nih.gov/pubmed/26013143
http://dx.doi.org/10.1007/s00109-015-1296-9

Ejemplares similares