Central GLP-1 receptor signalling accelerates plasma clearance of triacylglycerol and glucose by activating brown adipose tissue in mice

AIMS/HYPOTHESIS: Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism, used in the treatment of type 2 diabetes, has recently been shown to increase thermogenesis via the brain. As brown adipose tissue (BAT) produces heat by burning triacylglycerol (TG) and takes up glucose for de novo lipogene...

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Detalles Bibliográficos
Autores principales: Kooijman, Sander, Wang, Yanan, Parlevliet, Edwin T., Boon, Mariëtte R., Edelschaap, David, Snaterse, Gido, Pijl, Hanno, Romijn, Johannes A., Rensen, Patrick C. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589565/
https://www.ncbi.nlm.nih.gov/pubmed/26254578
http://dx.doi.org/10.1007/s00125-015-3727-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589565/
https://www.ncbi.nlm.nih.gov/pubmed/26254578
http://dx.doi.org/10.1007/s00125-015-3727-0

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