BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid

Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), responsible...

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Detalles Bibliográficos
Autores principales: Findlay, John A., Hamilton, David L., Ashford, Michael L. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589671/
https://www.ncbi.nlm.nih.gov/pubmed/26483636
http://dx.doi.org/10.3389/fncel.2015.00382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589671/
https://www.ncbi.nlm.nih.gov/pubmed/26483636
http://dx.doi.org/10.3389/fncel.2015.00382

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