Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene

Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm...

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Autores principales: Nithianantharajah, J., McKechanie, A. G., Stewart, T. J., Johnstone, M., Blackwood, D. H., St Clair, D., Grant, S. G. N., Bussey, T. J., Saksida, L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589696/
https://www.ncbi.nlm.nih.gov/pubmed/26423861
http://dx.doi.org/10.1038/srep14613
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author Nithianantharajah, J.
McKechanie, A. G.
Stewart, T. J.
Johnstone, M.
Blackwood, D. H.
St Clair, D.
Grant, S. G. N.
Bussey, T. J.
Saksida, L. M.
author_facet Nithianantharajah, J.
McKechanie, A. G.
Stewart, T. J.
Johnstone, M.
Blackwood, D. H.
St Clair, D.
Grant, S. G. N.
Bussey, T. J.
Saksida, L. M.
author_sort Nithianantharajah, J.
collection PubMed
description Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic.
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spelling pubmed-45896962015-10-13 Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene Nithianantharajah, J. McKechanie, A. G. Stewart, T. J. Johnstone, M. Blackwood, D. H. St Clair, D. Grant, S. G. N. Bussey, T. J. Saksida, L. M. Sci Rep Article Development of effective therapies for brain disorders has been hampered by a lack of translational cognitive testing methods. We present the first example of using the identical touchscreen-based cognitive test to assess mice and humans carrying disease-related genetic mutations. This new paradigm has significant implications for improving how we measure and model cognitive dysfunction in human disorders in animals, thus bridging the gap towards effective translation to the clinic. Nature Publishing Group 2015-10-01 /pmc/articles/PMC4589696/ /pubmed/26423861 http://dx.doi.org/10.1038/srep14613 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Nithianantharajah, J.
McKechanie, A. G.
Stewart, T. J.
Johnstone, M.
Blackwood, D. H.
St Clair, D.
Grant, S. G. N.
Bussey, T. J.
Saksida, L. M.
Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
title Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
title_full Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
title_fullStr Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
title_full_unstemmed Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
title_short Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
title_sort bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589696/
https://www.ncbi.nlm.nih.gov/pubmed/26423861
http://dx.doi.org/10.1038/srep14613
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