MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression

The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It is established that the transcription factor GATA-3 is induced in Treg cells under inflammatory conditions. GATA-3 stabilizes FOXP3 levels to avoid the differentiation of Treg cells into...

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Autores principales: Li, Dan, Kong, Chao, Tsun, Andy, Chen, Chen, Song, Huihui, Shi, Guochao, Pan, Wen, Dai, Dai, Shen, Nan, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589732/
https://www.ncbi.nlm.nih.gov/pubmed/26424054
http://dx.doi.org/10.1038/srep14615
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author Li, Dan
Kong, Chao
Tsun, Andy
Chen, Chen
Song, Huihui
Shi, Guochao
Pan, Wen
Dai, Dai
Shen, Nan
Li, Bin
author_facet Li, Dan
Kong, Chao
Tsun, Andy
Chen, Chen
Song, Huihui
Shi, Guochao
Pan, Wen
Dai, Dai
Shen, Nan
Li, Bin
author_sort Li, Dan
collection PubMed
description The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It is established that the transcription factor GATA-3 is induced in Treg cells under inflammatory conditions. GATA-3 stabilizes FOXP3 levels to avoid the differentiation of Treg cells into inflammatory-like T cells. The IL-6 signal pathway influences the sensitivity of Treg cells towards instability. The mechanism of GATA-3 in regulating FOXP3 and its relation to the IL-6 pathway remains unclear. Here we report how miR-125a-5p plays an important role in regulating the conversion of Treg cells by IL-6. miR-125a-5p expression is low in Treg cells under steady state conditions and can be induced by GATA-3 to inhibit the expression of IL-6R and STAT3. This finding reveals a GATA3/miR-125a-5p/IL-6R and STAT3/FOXP3 regulatory pathway, which determines how Treg cells respond to inflammatory IL-6-rich conditions.
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spelling pubmed-45897322015-10-13 MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression Li, Dan Kong, Chao Tsun, Andy Chen, Chen Song, Huihui Shi, Guochao Pan, Wen Dai, Dai Shen, Nan Li, Bin Sci Rep Article The transcription factor FOXP3 is essential for the differentiation and function of regulatory T cells (Treg). It is established that the transcription factor GATA-3 is induced in Treg cells under inflammatory conditions. GATA-3 stabilizes FOXP3 levels to avoid the differentiation of Treg cells into inflammatory-like T cells. The IL-6 signal pathway influences the sensitivity of Treg cells towards instability. The mechanism of GATA-3 in regulating FOXP3 and its relation to the IL-6 pathway remains unclear. Here we report how miR-125a-5p plays an important role in regulating the conversion of Treg cells by IL-6. miR-125a-5p expression is low in Treg cells under steady state conditions and can be induced by GATA-3 to inhibit the expression of IL-6R and STAT3. This finding reveals a GATA3/miR-125a-5p/IL-6R and STAT3/FOXP3 regulatory pathway, which determines how Treg cells respond to inflammatory IL-6-rich conditions. Nature Publishing Group 2015-10-01 /pmc/articles/PMC4589732/ /pubmed/26424054 http://dx.doi.org/10.1038/srep14615 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Dan
Kong, Chao
Tsun, Andy
Chen, Chen
Song, Huihui
Shi, Guochao
Pan, Wen
Dai, Dai
Shen, Nan
Li, Bin
MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
title MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
title_full MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
title_fullStr MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
title_full_unstemmed MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
title_short MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression
title_sort mir-125a-5p decreases the sensitivity of treg cells toward il-6-mediated conversion by inhibiting il-6r and stat3 expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589732/
https://www.ncbi.nlm.nih.gov/pubmed/26424054
http://dx.doi.org/10.1038/srep14615
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