Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essen...

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Detalles Bibliográficos
Autores principales: Fan, Xue-Yu, Tian, Chan, Wang, Hui, Xu, Yin, Ren, Ke, Zhang, Bao-Yun, Gao, Chen, Shi, Qi, Meng, Ge, Zhang, Lu-Bin, Zhao, Yang-Jing, Shao, Qi-Xiang, Dong, Xiao-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589734/
https://www.ncbi.nlm.nih.gov/pubmed/26423766
http://dx.doi.org/10.1038/srep14728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589734/
https://www.ncbi.nlm.nih.gov/pubmed/26423766
http://dx.doi.org/10.1038/srep14728

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