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Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essen...

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Detalles Bibliográficos
Autores principales:	Fan, Xue-Yu, Tian, Chan, Wang, Hui, Xu, Yin, Ren, Ke, Zhang, Bao-Yun, Gao, Chen, Shi, Qi, Meng, Ge, Zhang, Lu-Bin, Zhao, Yang-Jing, Shao, Qi-Xiang, Dong, Xiao-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589734/ https://www.ncbi.nlm.nih.gov/pubmed/26423766 http://dx.doi.org/10.1038/srep14728

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