NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor

The nuclear farnesoid X receptor (FXR) is a ligand activated transcription factor and acts as cellular sensor for bile acids. In this role, FXR is a highly important liver protector and FXR inhibition by antagonists or knockout has shown several deleterious effects. A recent report characterized non...

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Detalles Bibliográficos
Autores principales: Schmidt, Jurema, Klingler, Franca-Maria, Proschak, Ewgenji, Steinhilber, Dieter, Schubert-Zsilavecz, Manfred, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589779/
https://www.ncbi.nlm.nih.gov/pubmed/26424593
http://dx.doi.org/10.1038/srep14782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589779/
https://www.ncbi.nlm.nih.gov/pubmed/26424593
http://dx.doi.org/10.1038/srep14782

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