Pre-amyloid oligomers of the proteotoxic RepA-WH1 prionoid assemble at the bacterial nucleoid

Upon binding to short specific dsDNA sequences in vitro, the N-terminal WH1 domain of the plasmid DNA replication initiator RepA assembles as amyloid fibres. These are bundles of single or double twisted tubular filaments in which distorted RepA-WH1 monomers are the building blocks. When expressed i...

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Detalles Bibliográficos
Autores principales: Moreno-del Álamo, María, de la Espina, Susana Moreno-Díaz, Fernández-Tresguerres, M. Elena, Giraldo, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589793/
https://www.ncbi.nlm.nih.gov/pubmed/26423724
http://dx.doi.org/10.1038/srep14669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589793/
https://www.ncbi.nlm.nih.gov/pubmed/26423724
http://dx.doi.org/10.1038/srep14669

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