Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington’s disease

INTRODUCTION: The inhibition of the Histone Deacetylase 6 (HDAC6) increases tubulin acetylation, thus stimulating intracellular vesicle trafficking and brain-derived neurotrophic factor (BDNF) release, that is, cellular processes markedly reduced in Huntington’s disease (HD). METHODS: We therefore t...

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Detalles Bibliográficos
Autores principales: Ragot, Alienor, Pietropaolo, Susanna, Vincent, Jean, Delage, Pauline, Zhang, Hongyu, Allinquant, Bernadette, Leinekugel, Xavier, Fischer, André, Cho, Yoon H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589808/
https://www.ncbi.nlm.nih.gov/pubmed/26445700
http://dx.doi.org/10.1002/brb3.361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589808/
https://www.ncbi.nlm.nih.gov/pubmed/26445700
http://dx.doi.org/10.1002/brb3.361

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