The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events

Telomeric abnormalities caused by loss of function of the RecQ helicase WRN are linked to the multiple premature ageing phenotypes that characterize Werner syndrome. Here we examine WRN's role in telomeric maintenance, by comparing its action on a variety of DNA structures without or with telom...

Descripción completa

Detalles Bibliográficos
Autores principales: Edwards, Deanna N., Machwe, Amrita, Chen, Li, Bohr, Vilhelm A., Orren, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589872/
https://www.ncbi.nlm.nih.gov/pubmed/26420422
http://dx.doi.org/10.1038/ncomms9331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589872/
https://www.ncbi.nlm.nih.gov/pubmed/26420422
http://dx.doi.org/10.1038/ncomms9331

Ejemplares similares