A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

The capsaicin receptor TRPV1 ion channel is a polymodal nociceptor that responds to heat with exquisite sensitivity through an unknown mechanism. Here we report the identification of a novel toxin, RhTx, from the venom of the Chinese red-headed centipede that potently activates TRPV1 to produce excr...

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Detalles Bibliográficos
Autores principales: Yang, Shilong, Yang, Fan, Wei, Ningning, Hong, Jing, Li, Bowen, Luo, Lei, Rong, Mingqiang, Yarov-Yarovoy, Vladimir, Zheng, Jie, Wang, KeWei, Lai, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589873/
https://www.ncbi.nlm.nih.gov/pubmed/26420335
http://dx.doi.org/10.1038/ncomms9297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589873/
https://www.ncbi.nlm.nih.gov/pubmed/26420335
http://dx.doi.org/10.1038/ncomms9297

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