The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson's disease

In this study, we investigated the effect of an antibody against E3 ubiquitin ligase seven in absentia homolog 1 (SIAH-1) in PC12 cells. 1-Methyl-4-phenylpyridinium (MPP(+)) treatment increased α-synuclein, E1 and SIAH-1 protein levels in PC12 cells, and it reduced cell viability; however, there was...

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Detalles Bibliográficos
Autores principales: Cai, Zeng-lin, Xu, Jing, Xue, Shou-ru, Liu, Yuan-yuan, Zhang, Yong-jin, Zhang, Xin-zhi, Wang, Xuan, Wu, Fang-ping, Li, Xiao-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590242/
https://www.ncbi.nlm.nih.gov/pubmed/26487857
http://dx.doi.org/10.4103/1673-5374.162763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590242/
https://www.ncbi.nlm.nih.gov/pubmed/26487857
http://dx.doi.org/10.4103/1673-5374.162763

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