The PARK2/Parkin receptor on damaged mitochondria revisited—uncovering the role of phosphorylated ubiquitin chains

Phosphorylated ubiquitin produced by PINK1 kinase functions as a PARK2/Parkin activator by derepressing intramolecular autoinhibition of PARK2 E3 activity. Unexpectedly, we revealed that phosphorylated polyubiquitin chain also functions in the PARK2 recruitment process as a PARK2 receptor. Phosphory...

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Detalles Bibliográficos
Autores principales: Matsuda, Noriyuki, Tanaka, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590609/
https://www.ncbi.nlm.nih.gov/pubmed/26213095
http://dx.doi.org/10.1080/15548627.2015.1071760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590609/
https://www.ncbi.nlm.nih.gov/pubmed/26213095
http://dx.doi.org/10.1080/15548627.2015.1071760

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