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The PARK2/Parkin receptor on damaged mitochondria revisited—uncovering the role of phosphorylated ubiquitin chains
Phosphorylated ubiquitin produced by PINK1 kinase functions as a PARK2/Parkin activator by derepressing intramolecular autoinhibition of PARK2 E3 activity. Unexpectedly, we revealed that phosphorylated polyubiquitin chain also functions in the PARK2 recruitment process as a PARK2 receptor. Phosphory...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590609/ https://www.ncbi.nlm.nih.gov/pubmed/26213095 http://dx.doi.org/10.1080/15548627.2015.1071760 |