Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity

The HOPS tethering complex facilitates autophagosome-lysosome fusion by binding to Syx17 (Syntaxin 17), the autophagosomal SNARE. Here we show that loss of the core HOPS complex subunit Vps16A enhances autophagosome formation and slows down Drosophila development. Mechanistically, Tor kinase is less...

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Detalles Bibliográficos
Autores principales: Takáts, Szabolcs, Varga, Ágnes, Pircs, Karolina, Juhász, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Basic Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590676/
https://www.ncbi.nlm.nih.gov/pubmed/26061715
http://dx.doi.org/10.1080/15548627.2015.1059559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590676/
https://www.ncbi.nlm.nih.gov/pubmed/26061715
http://dx.doi.org/10.1080/15548627.2015.1059559

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