Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer

BACKGROUND: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) results in cell death. In recent years, SL has emerged as an attractive therapeutic strategy against cancer: by targeting t...

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Detalles Bibliográficos
Autores principales: Srihari, Sriganesh, Singla, Jitin, Wong, Limsoon, Ragan, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590705/
https://www.ncbi.nlm.nih.gov/pubmed/26427375
http://dx.doi.org/10.1186/s13062-015-0086-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590705/
https://www.ncbi.nlm.nih.gov/pubmed/26427375
http://dx.doi.org/10.1186/s13062-015-0086-1

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