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Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer
BACKGROUND: Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) results in cell death. In recent years, SL has emerged as an attractive therapeutic strategy against cancer: by targeting t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590705/ https://www.ncbi.nlm.nih.gov/pubmed/26427375 http://dx.doi.org/10.1186/s13062-015-0086-1 |