Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intrac...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Yongfeng, Dong, Jianbo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Geren, Isin N., Garcia-Rodriguez, Consuelo, Smith, Theresa J., Smith, Leonard A., Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Marks, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591640/
https://www.ncbi.nlm.nih.gov/pubmed/26343720
http://dx.doi.org/10.3390/toxins7093405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591640/
https://www.ncbi.nlm.nih.gov/pubmed/26343720
http://dx.doi.org/10.3390/toxins7093405

Ejemplares similares