Cargando…

Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B

Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intrac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Yongfeng, Dong, Jianbo, Lou, Jianlong, Wen, Weihua, Conrad, Fraser, Geren, Isin N., Garcia-Rodriguez, Consuelo, Smith, Theresa J., Smith, Leonard A., Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Marks, James D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591640/ https://www.ncbi.nlm.nih.gov/pubmed/26343720 http://dx.doi.org/10.3390/toxins7093405

Ejemplares similares

Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity
por: Fan, Yongfeng, et al.
Publicado: (2015)

A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes
por: Fan, Yongfeng, et al.
Publicado: (2017)

A Three Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotype E Subtypes
por: Garcia-Rodriguez, Consuelo, et al.
Publicado: (2018)

A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D
por: Garcia-Rodriguez, Consuelo, et al.
Publicado: (2021)

A Single Tri-Epitopic Antibody Virtually Recapitulates the Potency of a Combination of Three Monoclonal Antibodies in Neutralization of Botulinum Neurotoxin Serotype A
por: Lou, Jianlong, et al.
Publicado: (2018)

Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies
por: Kalb, Suzanne R., et al.
Publicado: (2009)

Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H
por: Fan, Yongfeng, et al.
Publicado: (2016)

Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies
por: Kalb, Suzanne R, et al.
Publicado: (2011)

Extraction of BoNT/A, /B, /E, and /F with a Single, High Affinity Monoclonal Antibody for Detection of Botulinum Neurotoxin by Endopep-MS
por: Kalb, Suzanne R., et al.
Publicado: (2010)

Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B
por: Cheng, Luisa W., et al.
Publicado: (2015)

Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B
por: Matsumura, Takuhiro, et al.
Publicado: (2020)

Botulinum Neurotoxins (BoNTs)—Antibody and Vaccine
por: Lou, Jianlong, et al.
Publicado: (2018)

Emerging Opportunities for Serotypes of Botulinum Neurotoxins
por: Peng Chen, Zhongxing, et al.
Publicado: (2012)

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination against Botulinum C and D Neurotoxins
por: Snow, Doris M., et al.
Publicado: (2019)

Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H
por: Hackett, Gavin, et al.
Publicado: (2018)

Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy
por: Savage, Alison C., et al.
Publicado: (2015)

Development of immunodetection system for botulinum neurotoxin serotype E
por: Sarita, R., et al.
Publicado: (2018)

Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum
por: Carter, Andrew T, et al.
Publicado: (2009)

A Monoclonal Antibody Based Capture ELISA for Botulinum Neurotoxin Serotype B: Toxin Detection in Food
por: Stanker, Larry H., et al.
Publicado: (2013)

Characterization of Serotype CD Mosaic Botulinum Neurotoxin in Comparison with Serotype C and A
por: Miyashita, Shin-Ichiro, et al.
Publicado: (2023)

Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E
por: Masuyer, Geoffrey, et al.
Publicado: (2021)

Recombinant botulinum neurotoxin serotype A1 in vivo characterization
por: Périer, Cindy, et al.
Publicado: (2021)

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
por: von Berg, Laura, et al.
Publicado: (2019)

Editorial: New insights on botulism, botulinum neurotoxins, and botulinum toxin-producing clostridia
por: Anniballi, Fabrizio, et al.
Publicado: (2022)

A human bispecific antibody neutralizes botulinum neurotoxin serotype A
por: Lu, Jiansheng, et al.
Publicado: (2023)

Development and Characterization of Monoclonal Antibodies to Botulinum Neurotoxin Type E
por: Bever, Candace S., et al.
Publicado: (2019)

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
por: Weisemann, Jasmin, et al.
Publicado: (2016)

Protein Domain Analysis of C. botulinum Type A Neurotoxin and Its Relationship with Other Botulinum Serotypes
por: Sharma, Shashi K., et al.
Publicado: (2009)

Universal and specific quantitative detection of botulinum neurotoxin genes
por: Hill, Brenna J, et al.
Publicado: (2010)

Translocation of botulinum neurotoxin serotype A and associated proteins across the intestinal epithelia
por: Lam, Tina I, et al.
Publicado: (2015)

Probiotic Microorganisms Inhibit Epithelial Cell Internalization of Botulinum Neurotoxin Serotype A
por: Lam, Tina I., et al.
Publicado: (2016)

On Botulinum Neurotoxin Variability
por: Montecucco, Cesare, et al.
Publicado: (2015)

Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A
por: Pang, Yuan-Ping, et al.
Publicado: (2010)

Llama Single Domain Antibodies Specific for the 7 Botulinum Neurotoxin Serotypes as Heptaplex Immunoreagents
por: Conway, Jerry O., et al.
Publicado: (2010)

A Simple, Rapid and Sensitive FRET Assay for Botulinum Neurotoxin Serotype B Detection
por: Guo, Jiubiao, et al.
Publicado: (2014)

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function
por: Tremblay, Jacqueline M., et al.
Publicado: (2020)

A Thermostable Dissolving Microneedle Vaccine with Recombinant Protein of Botulinum Neurotoxin Serotype A
por: Zhao, Baohua, et al.
Publicado: (2022)

The Novel Clostridial Neurotoxin Produced by Strain IBCA10-7060 Is Immunologically Equivalent to BoNT/HA
por: Fan, Yongfeng, et al.
Publicado: (2019)

Evidence that Plasmid-Borne Botulinum Neurotoxin Type B Genes Are Widespread among Clostridium botulinum Serotype B Strains
por: Franciosa, Giovanna, et al.
Publicado: (2009)

Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems
por: Elliott, Mark, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_9mtu0o4med5hd5jg734ff3v3ln