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STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites

The yeast transcription factor MATα2 (α2) is a short-lived protein known to be ubiquitylated by two distinct pathways, one involving the ubiquitin-conjugating enzymes (E2s) Ubc6 and Ubc7 and the ubiquitin ligase (E3) Doa10 and the other operating with the E2 Ubc4 and the heterodimeric E3 Slx5/Slx8....

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Detalles Bibliográficos
Autores principales: Hickey, Christopher M., Hochstrasser, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591686/
https://www.ncbi.nlm.nih.gov/pubmed/26246605
http://dx.doi.org/10.1091/mbc.E15-06-0436