PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis

In mutant INS gene–induced diabetes of youth (MIDY), characterized by insulin deficiency, MIDY proinsulin mutants misfold and fail to exit the endoplasmic reticulum (ER). Moreover, these mutants bind and block ER exit of wild-type (WT) proinsulin, inhibiting insulin production. The ultimate fate of...

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Detalles Bibliográficos
Autores principales: He, Kaiyu, Cunningham, Corey Nathaniel, Manickam, Nandini, Liu, Ming, Arvan, Peter, Tsai, Billy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591687/
https://www.ncbi.nlm.nih.gov/pubmed/26269577
http://dx.doi.org/10.1091/mbc.E15-01-0034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591687/
https://www.ncbi.nlm.nih.gov/pubmed/26269577
http://dx.doi.org/10.1091/mbc.E15-01-0034

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