Replication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast

DNA replication stress causes genome mutations, rearrangements, and chromosome missegregation, which are implicated in cancer. We analyze a fission yeast mutant that is unable to complete S phase due to a defective subunit of the MCM helicase. Despite underreplicated and damaged DNA, these cells eva...

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Detalles Bibliográficos
Autores principales: Sabatinos, Sarah A., Ranatunga, Nimna S., Yuan, Ji-Ping, Green, Marc D., Forsburg, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591689/
https://www.ncbi.nlm.nih.gov/pubmed/26246602
http://dx.doi.org/10.1091/mbc.E15-05-0318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591689/
https://www.ncbi.nlm.nih.gov/pubmed/26246602
http://dx.doi.org/10.1091/mbc.E15-05-0318

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