Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

Active Cdc42 GTPase, a key regulator of cell polarity, displays oscillatory dynamics that are anticorrelated at the two cell tips in fission yeast. Anticorrelation suggests competition for active Cdc42 or for its effectors. Here we show how 14-3-3 protein Rad24 associates with Cdc42 guanine exchange...

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Detalles Bibliográficos
Autores principales: Das, Maitreyi, Nuñez, Illyce, Rodriguez, Marbelys, Wiley, David J., Rodriguez, Juan, Sarkeshik, Ali, Yates, John R., Buchwald, Peter, Verde, Fulvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591695/
https://www.ncbi.nlm.nih.gov/pubmed/26246599
http://dx.doi.org/10.1091/mbc.E15-02-0095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591695/
https://www.ncbi.nlm.nih.gov/pubmed/26246599
http://dx.doi.org/10.1091/mbc.E15-02-0095

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