Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching

During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional orientation as adjacent Cμ constant region exons(1,2). In mice, six additional sets...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Junchao, Panchakshari, Rohit A., Zhang, Tingting, Zhang, Yu, Hu, Jiazhi, Volpi, Sabrina A., Meyers, Robin M., Ho, Yu-Jui, Du, Zhou, Robbiani, Davide F., Meng, Feilong, Gostissa, Monica, Nussenzweig, Michel C., Manis, John P., Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592165/
https://www.ncbi.nlm.nih.gov/pubmed/26308889
http://dx.doi.org/10.1038/nature14970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592165/
https://www.ncbi.nlm.nih.gov/pubmed/26308889
http://dx.doi.org/10.1038/nature14970

Ejemplares similares