Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

Interindividual variability in anatomical and physiological properties results in significant differences in drug pharmacokinetics. The consideration of such pharmacokinetic variability supports optimal drug efficacy and safety for each single individual, e.g. by identification of individual-specifi...

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Detalles Bibliográficos
Autores principales: Krauss, Markus, Tappe, Kai, Schuppert, Andreas, Kuepfer, Lars, Goerlitz, Linus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592188/
https://www.ncbi.nlm.nih.gov/pubmed/26431198
http://dx.doi.org/10.1371/journal.pone.0139423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592188/
https://www.ncbi.nlm.nih.gov/pubmed/26431198
http://dx.doi.org/10.1371/journal.pone.0139423

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