Exploration of Novel Inhibitors for Class I Histone Deacetylase Isoforms by QSAR Modeling and Molecular Dynamics Simulation Assays

Histone deacetylases (HDAC) are metal-dependent enzymes and considered as important targets for cell functioning. Particularly, higher expression of class I HDACs is common in the onset of multiple malignancies which results in deregulation of many target genes involved in cell growth, differentiati...

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Detalles Bibliográficos
Autores principales: Noor, Zainab, Afzal, Noreen, Rashid, Sajid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592208/
https://www.ncbi.nlm.nih.gov/pubmed/26431201
http://dx.doi.org/10.1371/journal.pone.0139588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592208/
https://www.ncbi.nlm.nih.gov/pubmed/26431201
http://dx.doi.org/10.1371/journal.pone.0139588

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