Development of Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Indomethacin Disposition in Pregnancy

Findings of a recent clinical study showed indomethacin has lower plasma levels and higher steady-state apparent clearance in pregnant subjects when compared to those in non-pregnant subjects reported in separate studies. Thus, in the current work we developed a pregnancy physiological based pharmac...

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Detalles Bibliográficos
Autores principales: Alqahtani, Saeed, Kaddoumi, Amal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592215/
https://www.ncbi.nlm.nih.gov/pubmed/26431339
http://dx.doi.org/10.1371/journal.pone.0139762

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592215/
https://www.ncbi.nlm.nih.gov/pubmed/26431339
http://dx.doi.org/10.1371/journal.pone.0139762

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