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A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties
BACKGROUND: Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD) from streptococcal protein G (SpG(C3)) as module for half-life extension....
Autores principales: | Unverdorben, Felix, Hutt, Meike, Seifert, Oliver, Kontermann, Roland E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592230/ https://www.ncbi.nlm.nih.gov/pubmed/26430884 http://dx.doi.org/10.1371/journal.pone.0139838 |
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