The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate

NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). In the current work, we found that NF449 inhibits virus attachment to target cells, and specifically blocks virus interaction with two identified receptor...

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Detalles Bibliográficos
Autores principales: Nishimura, Yorihiro, McLaughlin, Noel P., Pan, Jieyan, Goldstein, Sara, Hafenstein, Susan, Shimizu, Hiroyuki, Winkler, Jeffrey D., Bergelson, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592248/
https://www.ncbi.nlm.nih.gov/pubmed/26430888
http://dx.doi.org/10.1371/journal.ppat.1005184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592248/
https://www.ncbi.nlm.nih.gov/pubmed/26430888
http://dx.doi.org/10.1371/journal.ppat.1005184

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