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The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate
NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). In the current work, we found that NF449 inhibits virus attachment to target cells, and specifically blocks virus interaction with two identified receptor...
Autores principales: | Nishimura, Yorihiro, McLaughlin, Noel P., Pan, Jieyan, Goldstein, Sara, Hafenstein, Susan, Shimizu, Hiroyuki, Winkler, Jeffrey D., Bergelson, Jeffrey M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592248/ https://www.ncbi.nlm.nih.gov/pubmed/26430888 http://dx.doi.org/10.1371/journal.ppat.1005184 |
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