CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1

The CUL4-DDB1 E3 ligase complex serves as a critical regulator in various cellular processes, including cell proliferation, DNA damage repair, and cell cycle progression. However, whether this E3 ligase complex regulates clock protein turnover and the molecular clock activity in mammalian cells is u...

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Detalles Bibliográficos
Autores principales: Tong, Xin, Zhang, Deqiang, Guha, Anirvan, Arthurs, Blake, Cazares, Victor, Gupta, Neil, Yin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592254/
https://www.ncbi.nlm.nih.gov/pubmed/26431207
http://dx.doi.org/10.1371/journal.pone.0139725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592254/
https://www.ncbi.nlm.nih.gov/pubmed/26431207
http://dx.doi.org/10.1371/journal.pone.0139725

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