Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization

The small GTPase RhoA is involved in cell morphology and migration. RhoA activity is tightly regulated in time and space and depends on guanine exchange factors (GEFs). However, the kinetics and subcellular localization of GEF activity towards RhoA are poorly defined. To study the mechanism underlyi...

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Detalles Bibliográficos
Autores principales: van Unen, Jakobus, Reinhard, Nathalie R., Yin, Taofei, Wu, Yi I., Postma, Marten, Gadella, Theodorus W.J., Goedhart, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592971/
https://www.ncbi.nlm.nih.gov/pubmed/26435194
http://dx.doi.org/10.1038/srep14693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592971/
https://www.ncbi.nlm.nih.gov/pubmed/26435194
http://dx.doi.org/10.1038/srep14693

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