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An assessment of the amount of untapped fold level novelty in under-sampled areas of the tree of life

Previous studies of protein fold space suggest that fold coverage is plateauing. However, sequence sampling has been -and remains to a large extent- heavily biased, focusing on culturable phyla. Sustained technological developments have fuelled the advent of metagenomics and single-cell sequencing,...

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Detalles Bibliográficos
Autores principales: Barry Roche, Daniel, Brüls, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592975/
https://www.ncbi.nlm.nih.gov/pubmed/26434770
http://dx.doi.org/10.1038/srep14717