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An assessment of the amount of untapped fold level novelty in under-sampled areas of the tree of life
Previous studies of protein fold space suggest that fold coverage is plateauing. However, sequence sampling has been -and remains to a large extent- heavily biased, focusing on culturable phyla. Sustained technological developments have fuelled the advent of metagenomics and single-cell sequencing,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592975/ https://www.ncbi.nlm.nih.gov/pubmed/26434770 http://dx.doi.org/10.1038/srep14717 |