DNA Ligase I Is Not Essential for Mammalian Cell Viability

Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability. Here, we report the striking finding that a Lig1-null murine B cell line is viable. Surprisingly, the...

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Detalles Bibliográficos
Autores principales: Han, Li, Masani, Shahnaz, Hsieh, Chih-lin, Yu, Kefei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593317/
https://www.ncbi.nlm.nih.gov/pubmed/24726358
http://dx.doi.org/10.1016/j.celrep.2014.03.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593317/
https://www.ncbi.nlm.nih.gov/pubmed/24726358
http://dx.doi.org/10.1016/j.celrep.2014.03.024

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