Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles

In forebrain neurons, Ca(2+) triggers exocytosis of readily releasable vesicles by binding to synaptotagmin-1 and -7, thereby inducing fast and slow vesicle exocytosis, respectively. Loss-of-function of synaptotagmin-1 or -7 selectively impairs the fast and slow phase of release, respectively, but d...

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Detalles Bibliográficos
Autores principales: Bacaj, Taulant, Wu, Dick, Burré, Jacqueline, Malenka, Robert C., Liu, Xinran, Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593569/
https://www.ncbi.nlm.nih.gov/pubmed/26437117
http://dx.doi.org/10.1371/journal.pbio.1002267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593569/
https://www.ncbi.nlm.nih.gov/pubmed/26437117
http://dx.doi.org/10.1371/journal.pbio.1002267

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