The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway

Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated the role of PI3K/Akt in p50/p50 NF-κB activation and the effect on iNOS expression in L. amazonensis infection. The increased occupancy o...

Descripción completa

Detalles Bibliográficos
Autores principales: Calegari-Silva, Teresa C., Vivarini, Áislan C., Miqueline, Marina, Dos Santos, Guilherme R. R. M., Teixeira, Karina Luiza, Saliba, Alessandra Mattos, Nunes de Carvalho, Simone, de Carvalho, Laís, Lopes, Ulisses G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593669/
https://www.ncbi.nlm.nih.gov/pubmed/26400473
http://dx.doi.org/10.1098/rsob.150118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593669/
https://www.ncbi.nlm.nih.gov/pubmed/26400473
http://dx.doi.org/10.1098/rsob.150118

Ejemplares similares