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The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway
Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated the role of PI3K/Akt in p50/p50 NF-κB activation and the effect on iNOS expression in L. amazonensis infection. The increased occupancy o...
Autores principales: | Calegari-Silva, Teresa C., Vivarini, Áislan C., Miqueline, Marina, Dos Santos, Guilherme R. R. M., Teixeira, Karina Luiza, Saliba, Alessandra Mattos, Nunes de Carvalho, Simone, de Carvalho, Laís, Lopes, Ulisses G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593669/ https://www.ncbi.nlm.nih.gov/pubmed/26400473 http://dx.doi.org/10.1098/rsob.150118 |
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